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Independent analysis of NHS open data
PharmaInsight

Chlorothiazide vs Eplerenone

National NHS prescribing compared (Prescription Cost Analysis)
Data updated May 2026

Eplerenone was dispensed 1,303.4× as often as Chlorothiazide in May 2026 — 181,173 items versus 139 in England.

139items

Chlorothiazide · May 2026

NHSBSA Prescription Cost Analysis

181,173items

Eplerenone · May 2026

NHSBSA Prescription Cost Analysis

Figure 1. Chlorothiazide versus Eplerenone: national items dispensed by month

▬ Chlorothiazide   ·   ╌ Eplerenone

0 93k 186k Jan 2021 Nov 2021 Sep 2022 Jul 2023 May 2024 Mar 2025 May 2026 Eplerenone 139 Jan 2021: 226 Feb 2021: 219 Mar 2021: 226 Apr 2021: 233 May 2021: 200 Jun 2021: 221 Jul 2021: 194 Aug 2021: 190 Sep 2021: 202 Oct 2021: 202 Nov 2021: 182 Dec 2021: 183 Jan 2022: 197 Feb 2022: 155 Mar 2022: 197 Apr 2022: 163 May 2022: 182 Jun 2022: 187 Jul 2022: 188 Aug 2022: 191 Sep 2022: 168 Oct 2022: 191 Nov 2022: 181 Dec 2022: 180 Jan 2023: 208 Feb 2023: 179 Mar 2023: 209 Apr 2023: 157 May 2023: 202 Jun 2023: 189 Jul 2023: 191 Aug 2023: 191 Sep 2023: 180 Oct 2023: 189 Nov 2023: 208 Dec 2023: 219 Jan 2024: 218 Feb 2024: 180 Mar 2024: 190 Apr 2024: 187 May 2024: 198 Jun 2024: 171 Jul 2024: 182 Aug 2024: 167 Sep 2024: 176 Oct 2024: 150 Nov 2024: 162 Dec 2024: 155 Jan 2025: 183 Feb 2025: 145 Mar 2025: 155 Apr 2025: 156 May 2025: 139 Jun 2025: 169 Jul 2025: 159 Aug 2025: 143 Sep 2025: 131 Oct 2025: 156 Nov 2025: 136 Dec 2025: 133 Jan 2026: 130 Feb 2026: 111 Mar 2026: 143 Apr 2026: 147 May 2026: 139

Source: NHSBSA Prescription Cost Analysis, to May 2026

Chlorothiazide versus Eplerenone, May 2026
Measure Chlorothiazide Eplerenone
Items, May 2026 139 181,173
Items, last 12 months 1,697 2,091,298
Net ingredient cost, May 2026 £6,852 £432,312

See the full profile for Chlorothiazide or Eplerenone.