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Independent analysis of NHS open data
PharmaInsight

Co-phenotrope (Diphenox hydrochloride/atropine sulfate) vs Loperamide hydrochloride and simeticone

National NHS prescribing compared (Prescription Cost Analysis)
Data updated May 2026

Loperamide hydrochloride and simeticone was dispensed 2.9× as often as Co-phenotrope (Diphenox hydrochloride/atropine sulfate) in May 2026 — 176 items versus 61 in England.

61items

Co-phenotrope (Diphenox hydrochloride/atropine sulfate) · May 2026

NHSBSA Prescription Cost Analysis

176items

Loperamide hydrochloride and simeticone · May 2026

NHSBSA Prescription Cost Analysis

Figure 1. Co-phenotrope (Diphenox hydrochloride/atropine sulfate) versus Loperamide hydrochloride and simeticone: national items dispensed by month

▬ Co-phenotrope (Diphenox hydrochloride/atropine sulfate)   ·   ╌ Loperamide hydrochloride and simeticone

0 125 250 Jan 2021 Nov 2021 Sep 2022 Jul 2023 May 2024 Mar 2025 May 2026 Loperamide hydro… 61 Jan 2021: 123 Feb 2021: 69 Mar 2021: 91 Apr 2021: 107 May 2021: 163 Jun 2021: 72 Jul 2021: 89 Aug 2021: 100 Sep 2021: 94 Oct 2021: 122 Nov 2021: 85 Dec 2021: 79 Jan 2022: 149 Feb 2022: 101 Mar 2022: 93 Apr 2022: 101 May 2022: 99 Jun 2022: 96 Jul 2022: 107 Aug 2022: 98 Sep 2022: 79 Oct 2022: 98 Nov 2022: 109 Dec 2022: 141 Jan 2023: 137 Feb 2023: 102 Mar 2023: 88 Apr 2023: 92 May 2023: 144 Jun 2023: 80 Jul 2023: 133 Aug 2023: 79 Sep 2023: 109 Oct 2023: 87 Nov 2023: 106 Dec 2023: 105 Jan 2024: 75 Feb 2024: 111 Mar 2024: 119 Apr 2024: 136 May 2024: 103 Jun 2024: 88 Jul 2024: 123 Aug 2024: 111 Sep 2024: 96 Oct 2024: 101 Nov 2024: 95 Dec 2024: 70 Jan 2025: 82 Feb 2025: 64 Mar 2025: 189 Apr 2025: 85 May 2025: 95 Jun 2025: 91 Jul 2025: 97 Aug 2025: 90 Sep 2025: 101 Oct 2025: 86 Nov 2025: 90 Dec 2025: 98 Jan 2026: 92 Feb 2026: 77 Mar 2026: 98 Apr 2026: 86 May 2026: 61

Source: NHSBSA Prescription Cost Analysis, to May 2026

Co-phenotrope (Diphenox hydrochloride/atropine sulfate) versus Loperamide hydrochloride and simeticone, May 2026
Measure Co-phenotrope (Diphenox hydrochloride/atropine sulfate) Loperamide hydrochloride and simeticone
Items, May 2026 61 176
Items, last 12 months 1,067 2,338
Net ingredient cost, May 2026 £17,037 £5,147

See the full profile for Co-phenotrope (Diphenox hydrochloride/atropine sulfate) or Loperamide hydrochloride and simeticone.