Skip to content
PharmaInsight

Donepezil hydrochloride vs Memantine hydrochloride

National NHS prescribing compared (Prescription Cost Analysis)
Data updated March 2026

Memantine hydrochloride was dispensed 1.2× as often as Donepezil hydrochloride in March 2026 — 206,334 items versus 177,911 in England.

177,911items

Donepezil hydrochloride · March 2026

NHSBSA Prescription Cost Analysis

206,334items

Memantine hydrochloride · March 2026

NHSBSA Prescription Cost Analysis

Figure 1. Donepezil hydrochloride versus Memantine hydrochloride: national items dispensed by month

▬ Donepezil hydrochloride   ·   ╌ Memantine hydrochloride

Memantine hydroc… 177,911

Source: NHSBSA Prescription Cost Analysis, to March 2026

Donepezil hydrochloride versus Memantine hydrochloride, March 2026
Measure Donepezil hydrochloride Memantine hydrochloride
Items, March 2026 177,911 206,334
Items, last 12 months 2,111,868 2,394,901
Net ingredient cost, March 2026 £481,987 £633,204

See the full profile for Donepezil hydrochloride or Memantine hydrochloride.