Skip to content
Independent analysis of NHS open data
PharmaInsight

Doxycycline hyclate vs Trimethoprim

National NHS prescribing compared (Prescription Cost Analysis)
Data updated May 2026

Doxycycline hyclate was dispensed 2.4× as often as Trimethoprim in May 2026 — 288,869 items versus 119,157 in England.

288,869items

Doxycycline hyclate · May 2026

NHSBSA Prescription Cost Analysis

119,157items

Trimethoprim · May 2026

NHSBSA Prescription Cost Analysis

Figure 1. Doxycycline hyclate versus Trimethoprim: national items dispensed by month

▬ Doxycycline hyclate   ·   ╌ Trimethoprim

0 306k 613k Jan 2021 Nov 2021 Sep 2022 Jul 2023 May 2024 Mar 2025 May 2026 Trimethoprim 288,869 Jan 2021: 252k Feb 2021: 195k Mar 2021: 209k Apr 2021: 198k May 2021: 194k Jun 2021: 212k Jul 2021: 222k Aug 2021: 214k Sep 2021: 261k Oct 2021: 308k Nov 2021: 334k Dec 2021: 361k Jan 2022: 302k Feb 2022: 252k Mar 2022: 313k Apr 2022: 298k May 2022: 271k Jun 2022: 264k Jul 2022: 259k Aug 2022: 236k Sep 2022: 256k Oct 2022: 332k Nov 2022: 360k Dec 2022: 613k Jan 2023: 502k Feb 2023: 365k Mar 2023: 390k Apr 2023: 314k May 2023: 311k Jun 2023: 281k Jul 2023: 265k Aug 2023: 282k Sep 2023: 271k Oct 2023: 345k Nov 2023: 387k Dec 2023: 444k Jan 2024: 486k Feb 2024: 401k Mar 2024: 388k Apr 2024: 387k May 2024: 351k Jun 2024: 301k Jul 2024: 312k Aug 2024: 253k Sep 2024: 273k Oct 2024: 371k Nov 2024: 383k Dec 2024: 474k Jan 2025: 477k Feb 2025: 361k Mar 2025: 353k Apr 2025: 329k May 2025: 295k Jun 2025: 273k Jul 2025: 255k Aug 2025: 233k Sep 2025: 277k Oct 2025: 359k Nov 2025: 341k Dec 2025: 447k Jan 2026: 447k Feb 2026: 351k Mar 2026: 360k Apr 2026: 328k May 2026: 289k

Source: NHSBSA Prescription Cost Analysis, to May 2026

Doxycycline hyclate versus Trimethoprim, May 2026
Measure Doxycycline hyclate Trimethoprim
Items, May 2026 288,869 119,157
Items, last 12 months 3,959,142 1,561,883
Net ingredient cost, May 2026 £345,142 £591,028

See the full profile for Doxycycline hyclate or Trimethoprim.