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Independent analysis of NHS open data
PharmaInsight

Hydrochlorothiazide vs Eplerenone

National NHS prescribing compared (Prescription Cost Analysis)
Data updated May 2026

Eplerenone was dispensed 1,561.8× as often as Hydrochlorothiazide in May 2026 — 181,173 items versus 116 in England.

116items

Hydrochlorothiazide · May 2026

NHSBSA Prescription Cost Analysis

181,173items

Eplerenone · May 2026

NHSBSA Prescription Cost Analysis

Figure 1. Hydrochlorothiazide versus Eplerenone: national items dispensed by month

▬ Hydrochlorothiazide   ·   ╌ Eplerenone

0 93k 186k Jan 2021 Nov 2021 Sep 2022 Jul 2023 May 2024 Mar 2025 May 2026 Eplerenone 116 Jan 2021: 110 Feb 2021: 76 Mar 2021: 152 Apr 2021: 119 May 2021: 116 Jun 2021: 97 Jul 2021: 114 Aug 2021: 117 Sep 2021: 123 Oct 2021: 83 Nov 2021: 114 Dec 2021: 78 Jan 2022: 121 Feb 2022: 116 Mar 2022: 246 Apr 2022: 235 May 2022: 244 Jun 2022: 157 Jul 2022: 160 Aug 2022: 151 Sep 2022: 160 Oct 2022: 147 Nov 2022: 147 Dec 2022: 146 Jan 2023: 168 Feb 2023: 132 Mar 2023: 158 Apr 2023: 148 May 2023: 187 Jun 2023: 174 Jul 2023: 158 Aug 2023: 150 Sep 2023: 188 Oct 2023: 147 Nov 2023: 164 Dec 2023: 145 Jan 2024: 159 Feb 2024: 133 Mar 2024: 126 Apr 2024: 155 May 2024: 142 Jun 2024: 131 Jul 2024: 133 Aug 2024: 146 Sep 2024: 128 Oct 2024: 143 Nov 2024: 126 Dec 2024: 151 Jan 2025: 146 Feb 2025: 130 Mar 2025: 130 Apr 2025: 135 May 2025: 129 Jun 2025: 128 Jul 2025: 138 Aug 2025: 134 Sep 2025: 143 Oct 2025: 139 Nov 2025: 143 Dec 2025: 98 Jan 2026: 119 Feb 2026: 99 Mar 2026: 134 Apr 2026: 121 May 2026: 116

Source: NHSBSA Prescription Cost Analysis, to May 2026

Hydrochlorothiazide versus Eplerenone, May 2026
Measure Hydrochlorothiazide Eplerenone
Items, May 2026 116 181,173
Items, last 12 months 1,512 2,091,298
Net ingredient cost, May 2026 £2,950 £432,312

See the full profile for Hydrochlorothiazide or Eplerenone.