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Independent analysis of NHS open data
PharmaInsight

Zoledronic acid vs Denosumab

National NHS prescribing compared (Prescription Cost Analysis)
Data updated April 2026

Denosumab was dispensed 3,596.0× as often as Zoledronic acid in April 2026 — 10,788 items versus 3 in England.

3items

Zoledronic acid · April 2026

NHSBSA Prescription Cost Analysis

10,788items

Denosumab · April 2026

NHSBSA Prescription Cost Analysis

Figure 1. Zoledronic acid versus Denosumab: national items dispensed by month

▬ Zoledronic acid   ·   ╌ Denosumab

0 5k 11k Jan 2021 Nov 2021 Sep 2022 Jul 2023 May 2024 Mar 2025 Apr 2026 Denosumab 3 Jan 2021: 4 Feb 2021: 5 Mar 2021: 5 Apr 2021: 4 May 2021: 7 Jun 2021: 9 Jul 2021: 6 Aug 2021: 4 Sep 2021: 2 Oct 2021: 4 Nov 2021: 6 Dec 2021: 4 Jan 2022: 13 Feb 2022: 4 Mar 2022: 9 Apr 2022: 3 May 2022: 6 Jun 2022: 4 Jul 2022: 5 Aug 2022: 8 Sep 2022: 5 Oct 2022: 5 Nov 2022: 2 Dec 2022: 5 Jan 2023: 3 Feb 2023: 3 Mar 2023: 7 Apr 2023: 5 May 2023: 4 Jun 2023: 4 Jul 2023: 4 Aug 2023: 5 Sep 2023: 4 Oct 2023: 6 Nov 2023: 10 Dec 2023: 3 Jan 2024: 7 Feb 2024: 1 Mar 2024: 6 Apr 2024: 5 May 2024: 7 Jun 2024: 10 Jul 2024: 4 Aug 2024: 3 Sep 2024: 1 Oct 2024: 6 Nov 2024: 6 Dec 2024: 8 Jan 2025: 3 Feb 2025: 3 Mar 2025: 6 Apr 2025: 4 May 2025: 4 Jun 2025: 5 Jul 2025: 1 Aug 2025: 2 Sep 2025: 5 Oct 2025: 1 Nov 2025: 1 Dec 2025: 6 Jan 2026: 2 Feb 2026: 1 Mar 2026: 1 Apr 2026: 3

Source: NHSBSA Prescription Cost Analysis, to April 2026

Zoledronic acid versus Denosumab, April 2026
Measure Zoledronic acid Denosumab
Items, April 2026 3 10,788
Items, last 12 months 32 122,862
Net ingredient cost, April 2026 £344 £1,911,627

See the full profile for Zoledronic acid or Denosumab.