Amitriptyline hydrochloride vs Lofepramine hydrochloride

National NHS prescribing compared (Prescription Cost Analysis)

Data updated March 2026

Amitriptyline hydrochloride was dispensed 157.4× as often as Lofepramine hydrochloride in March 2026 — 1,420,123 items versus 9,021 in England.

1,420,123items

Amitriptyline hydrochloride · March 2026

NHSBSA Prescription Cost Analysis

9,021items

Lofepramine hydrochloride · March 2026

NHSBSA Prescription Cost Analysis

Figure 1. Amitriptyline hydrochloride versus Lofepramine hydrochloride: national items dispensed by month

▬ Amitriptyline hydrochloride · ╌ Lofepramine hydrochloride

Source: NHSBSA Prescription Cost Analysis, to March 2026

Amitriptyline hydrochloride versus Lofepramine hydrochloride, March 2026
Measure	Amitriptyline hydrochloride	Lofepramine hydrochloride
Items, March 2026	1,420,123	9,021
Items, last 12 months	16,560,644	110,196
Net ingredient cost, March 2026	£1,545,559	£221,337