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Independent analysis of NHS open data
PharmaInsight

Amitriptyline hydrochloride

Central Nervous System Antidepressant drugs BNF 0403010B0
Data updated April 2026 Download CSV

Amitriptyline hydrochloride was the 12th most-dispensed medicine in England in April 2026, with 1,391,201 items, up 3.1% on a year earlier.

1,391,201items +3.1%

Dispensed in April 2026

15,211,002items

Rolling 12 months

£1,479,770

Net ingredient cost · April 2026

Figure 1. Amitriptyline hydrochloride: national items dispensed by month

0 728k 1.5m Jan 2021 Nov 2021 Sep 2022 Jul 2023 May 2024 Mar 2025 Apr 2026 1,391,201 Jan 2021: 1.2m Feb 2021: 1.2m Mar 2021: 1.3m Apr 2021: 1.3m May 2021: 1.2m Jun 2021: 1.3m Jul 2021: 1.3m Aug 2021: 1.2m Sep 2021: 1.3m Oct 2021: 1.2m Nov 2021: 1.3m Dec 2021: 1.3m Jan 2022: 1.3m Feb 2022: 1.2m Mar 2022: 1.3m Apr 2022: 1.2m May 2022: 1.3m Jun 2022: 1.3m Jul 2022: 1.2m Aug 2022: 1.3m Sep 2022: 1.3m Oct 2022: 1.3m Nov 2022: 1.3m Dec 2022: 1.3m Jan 2023: 1.3m Feb 2023: 1.2m Mar 2023: 1.4m Apr 2023: 1.2m May 2023: 1.3m Jun 2023: 1.3m Jul 2023: 1.3m Aug 2023: 1.3m Sep 2023: 1.3m Oct 2023: 1.3m Nov 2023: 1.3m Dec 2023: 1.3m Jan 2024: 1.4m Feb 2024: 1.3m Mar 2024: 1.3m Apr 2024: 1.4m May 2024: 1.4m Jun 2024: 1.3m Jul 2024: 1.4m Aug 2024: 1.3m Sep 2024: 1.3m Oct 2024: 1.4m Nov 2024: 1.3m Dec 2024: 1.4m Jan 2025: 1.4m Feb 2025: 1.3m Mar 2025: 1.3m Apr 2025: 1.3m May 2025: 1.4m Jun 2025: 1.3m Jul 2025: 1.4m Aug 2025: 1.3m Sep 2025: 1.4m Oct 2025: 1.4m Nov 2025: 1.3m Dec 2025: 1.5m Jan 2026: 1.4m Feb 2026: 1.3m Mar 2026: 1.4m Apr 2026: 1.4m

Source: NHSBSA Prescription Cost Analysis, to April 2026

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At a glance

  • Therapeutic class Antidepressant drugs
  • Presentations 7 shown
  • Average cost / item £1.06
  • Year on year Up 3.1% on a year earlier
What this is
Net ingredient cost is the list price before discounts and dispensing fees, not what the NHS finally pays.

Top presentations, April 2026

The individual products dispensed under Amitriptyline hydrochloride this month.

Presentations of Amitriptyline hydrochloride, April 2026
Presentation BNF code Items Net ingredient cost
Amitriptyline 10mg tablets 0403010B0AAAGAG 967,738 £1,019,982
Amitriptyline 25mg tablets 0403010B0AAAHAH 255,027 £232,885
Amitriptyline 50mg tablets 0403010B0AAAIAI 164,887 £139,341
Amitriptyline 25mg/5ml oral solution sugar free 0403010B0AAANAN 2,088 £31,377
Amitriptyline 10mg/5ml oral solution sugar free 0403010B0AABCBC 732 £40,464
Amitriptyline 50mg/5ml oral solution sugar free 0403010B0AAAFAF 725 £15,466
Amitriptyline 10mg/5ml oral liquid 0403010B0AAA6A6 4 £256

Source: NHSBSA Prescription Cost Analysis · to April 2026 OGL v3.0

Where Amitriptyline hydrochloride is dispensed

The regions and dispensing practices with the highest Amitriptyline hydrochloride volumes.

Regional volumes from NHSBSA Prescription Cost Analysis; practice volumes from NHS dispensing data.

Compare Amitriptyline hydrochloride with

Other medicines in the same BNF section, by prescribing volume.