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Independent analysis of NHS open data
PharmaInsight

Chlorambucil vs Methotrexate

National NHS prescribing compared (Prescription Cost Analysis)
Data updated May 2025

Methotrexate was dispensed 1,612.5× as often as Chlorambucil in May 2025 — 3,225 items versus 2 in England.

2items

Chlorambucil · May 2025

NHSBSA Prescription Cost Analysis

3,225items

Methotrexate · May 2025

NHSBSA Prescription Cost Analysis

Figure 1. Chlorambucil versus Methotrexate: national items dispensed by month

▬ Chlorambucil   ·   ╌ Methotrexate

0 2k 4k Jan 2021 Aug 2021 Mar 2022 Jan 2023 Aug 2023 Feb 2024 May 2025 Methotrexate 2 Jan 2021: 1 Mar 2021: 1 May 2021: 1 Jun 2021: 2 Jul 2021: 1 Aug 2021: 1 Sep 2021: 1 Dec 2021: 1 Jan 2022: 2 Feb 2022: 2 Mar 2022: 2 Apr 2022: 2 Jun 2022: 1 Aug 2022: 1 Nov 2022: 3 Jan 2023: 1 Feb 2023: 2 Apr 2023: 4 Jun 2023: 3 Jul 2023: 2 Aug 2023: 2 Sep 2023: 1 Nov 2023: 1 Dec 2023: 1 Jan 2024: 4 Feb 2024: 2 Mar 2024: 1 Apr 2024: 3 Nov 2024: 1 Jan 2025: 1 May 2025: 2

Source: NHSBSA Prescription Cost Analysis, to May 2025

Chlorambucil versus Methotrexate, May 2025
Measure Chlorambucil Methotrexate
Items, May 2025 2 3,225
Items, last 12 months 21 40,622
Net ingredient cost, May 2025 £24 £213,236

See the full profile for Chlorambucil or Methotrexate.