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Independent analysis of NHS open data
PharmaInsight

Cyclophosphamide vs Methotrexate

National NHS prescribing compared (Prescription Cost Analysis)
Data updated April 2026

Methotrexate was dispensed 551.8× as often as Cyclophosphamide in April 2026 — 3,311 items versus 6 in England.

6items

Cyclophosphamide · April 2026

NHSBSA Prescription Cost Analysis

3,311items

Methotrexate · April 2026

NHSBSA Prescription Cost Analysis

Figure 1. Cyclophosphamide versus Methotrexate: national items dispensed by month

▬ Cyclophosphamide   ·   ╌ Methotrexate

0 2k 4k Jan 2021 Oct 2021 Jul 2022 Apr 2023 Jan 2024 Oct 2024 Apr 2026 Methotrexate 6 Jan 2021: 26 Feb 2021: 22 Mar 2021: 31 Apr 2021: 24 May 2021: 20 Jun 2021: 23 Jul 2021: 23 Aug 2021: 28 Sep 2021: 23 Oct 2021: 28 Nov 2021: 24 Dec 2021: 27 Jan 2022: 20 Feb 2022: 15 Mar 2022: 16 Apr 2022: 21 May 2022: 12 Jun 2022: 12 Jul 2022: 17 Aug 2022: 15 Sep 2022: 15 Oct 2022: 7 Nov 2022: 11 Dec 2022: 10 Jan 2023: 5 Feb 2023: 10 Mar 2023: 10 Apr 2023: 7 May 2023: 6 Jun 2023: 9 Jul 2023: 8 Aug 2023: 5 Sep 2023: 6 Oct 2023: 15 Nov 2023: 9 Dec 2023: 9 Jan 2024: 11 Feb 2024: 6 Mar 2024: 6 Apr 2024: 6 May 2024: 11 Jun 2024: 5 Jul 2024: 4 Aug 2024: 3 Sep 2024: 3 Oct 2024: 2 Nov 2024: 4 Dec 2024: 4 Jan 2025: 5 Feb 2025: 4 Mar 2025: 4 May 2025: 3 Jun 2025: 3 Jul 2025: 3 Aug 2025: 4 Sep 2025: 2 Nov 2025: 1 Dec 2025: 1 Apr 2026: 6

Source: NHSBSA Prescription Cost Analysis, to April 2026

Cyclophosphamide versus Methotrexate, April 2026
Measure Cyclophosphamide Methotrexate
Items, April 2026 6 3,311
Items, last 12 months 40 40,937
Net ingredient cost, April 2026 £585 £218,895

See the full profile for Cyclophosphamide or Methotrexate.