Diphenhydramine hydrochloride vs Promethazine hydrochloride
National NHS prescribing compared (Prescription Cost Analysis)
Promethazine hydrochloride was dispensed 105.7× as often as Diphenhydramine hydrochloride in May 2026 — 234,806 items versus 2,222 in England.
2,222items
Diphenhydramine hydrochloride · May 2026
NHSBSA Prescription Cost Analysis
234,806items
Promethazine hydrochloride · May 2026
NHSBSA Prescription Cost Analysis
Figure 1. Diphenhydramine hydrochloride versus Promethazine hydrochloride: national items dispensed by month
▬ Diphenhydramine hydrochloride · ╌ Promethazine hydrochloride
Source: NHSBSA Prescription Cost Analysis, to May 2026
| Measure | Diphenhydramine hydrochloride | Promethazine hydrochloride |
|---|---|---|
| Items, May 2026 | 2,222 | 234,806 |
| Items, last 12 months | 28,714 | 2,912,461 |
| Net ingredient cost, May 2026 | £11,170 | £437,542 |
See the full profile for Diphenhydramine hydrochloride or Promethazine hydrochloride.