Diphenhydramine hydrochloride

National NHS prescribing (Prescription Cost Analysis) · Antihistamines, hyposensitisation and allergic emergencies

Data updated March 2026

Diphenhydramine hydrochloride was ranked 743rd of 1,794 medicines by items in March 2026, with 2,386 items, down 2.6% on a year earlier.

2,386items

Dispensed in March 2026

NHSBSA Prescription Cost Analysis

£12,041

Net ingredient cost · March 2026

NHSBSA PCA

28,945items

Dispensed in the last 12 months

NHSBSA PCA

Figure 1. Diphenhydramine hydrochloride: national items dispensed by month

Source: NHSBSA Prescription Cost Analysis, to March 2026

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Top presentations, March 2026

The individual products dispensed under Diphenhydramine hydrochloride, by items this month.

Presentations of Diphenhydramine hydrochloride, March 2026
Presentation	Items	Net ingredient cost
Diphenhydramine 25mg tablets	1,140	£5,335
Diphenhydramine 50mg tablets	1,134	£5,663
Nytol One-A-Night 50mg tablets	99	£699
Histergan 10mg/5ml syrup	13	£344

Compare Diphenhydramine hydrochloride with

Other medicines in the same BNF section, by prescribing volume.