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Fexofenadine hydrochloride vs Diphenhydramine hydrochloride

National NHS prescribing compared (Prescription Cost Analysis)
Data updated March 2026

Fexofenadine hydrochloride was dispensed 260.6× as often as Diphenhydramine hydrochloride in March 2026 — 621,716 items versus 2,386 in England.

621,716items

Fexofenadine hydrochloride · March 2026

NHSBSA Prescription Cost Analysis

2,386items

Diphenhydramine hydrochloride · March 2026

NHSBSA Prescription Cost Analysis

Figure 1. Fexofenadine hydrochloride versus Diphenhydramine hydrochloride: national items dispensed by month

▬ Fexofenadine hydrochloride   ·   ╌ Diphenhydramine hydrochloride

Diphenhydramine… 621,716

Source: NHSBSA Prescription Cost Analysis, to March 2026

Fexofenadine hydrochloride versus Diphenhydramine hydrochloride, March 2026
Measure Fexofenadine hydrochloride Diphenhydramine hydrochloride
Items, March 2026 621,716 2,386
Items, last 12 months 7,058,089 28,945
Net ingredient cost, March 2026 £2,288,270 £12,041

See the full profile for Fexofenadine hydrochloride or Diphenhydramine hydrochloride.