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Independent analysis of NHS open data
PharmaInsight

Hydrocortisone acetate vs Methotrexate

National NHS prescribing compared (Prescription Cost Analysis)
Data updated December 2025

Methotrexate was dispensed 182,888.0× as often as Hydrocortisone acetate in December 2025 — 182,888 items versus 1 in England.

1items

Hydrocortisone acetate · December 2025

NHSBSA Prescription Cost Analysis

182,888items

Methotrexate · December 2025

NHSBSA Prescription Cost Analysis

Figure 1. Hydrocortisone acetate versus Methotrexate: national items dispensed by month

▬ Hydrocortisone acetate   ·   ╌ Methotrexate

0 99k 198k Jan 2021 Jun 2021 Nov 2021 Apr 2022 Sep 2022 Feb 2023 Dec 2025 Methotrexate 1 Jan 2021: 4 Feb 2021: 4 Mar 2021: 2 Apr 2021: 7 May 2021: 6 Jun 2021: 8 Jul 2021: 4 Aug 2021: 4 Sep 2021: 3 Oct 2021: 10 Nov 2021: 9 Dec 2021: 4 Jan 2022: 2 Feb 2022: 2 Mar 2022: 3 Apr 2022: 3 May 2022: 7 Jun 2022: 5 Jul 2022: 5 Aug 2022: 6 Sep 2022: 5 Oct 2022: 3 Nov 2022: 6 Dec 2022: 3 Jan 2023: 6 Feb 2023: 1 Apr 2023: 1 Aug 2023: 1 Sep 2023: 2 Oct 2023: 2 Jun 2024: 1 Jul 2025: 1 Dec 2025: 1

Source: NHSBSA Prescription Cost Analysis, to December 2025

Hydrocortisone acetate versus Methotrexate, December 2025
Measure Hydrocortisone acetate Methotrexate
Items, December 2025 1 182,888
Items, last 12 months 28 2,236,227
Net ingredient cost, December 2025 £27 £2,247,752

See the full profile for Hydrocortisone acetate or Methotrexate.