Medicines
Musculoskeletal and Joint Diseases
Drugs used in rheumatic diseases and gout
Methotrexate

Methotrexate

Musculoskeletal and Joint Diseases Drugs used in rheumatic diseases and gout BNF 1001030U0

Data updated April 2026 Download CSV

Methotrexate was ranked 122nd of 1,792 medicines by items in April 2026, with 187,649 items, up 3.1% on a year earlier.

187,649items +3.1%

Dispensed in April 2026

2,053,339items

Rolling 12 months

£2,311,461

Net ingredient cost · April 2026

Figure 1. Methotrexate: national items dispensed by month

Source: NHSBSA Prescription Cost Analysis, to April 2026

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At a glance

Therapeutic class Drugs used in rheumatic diseases and gout
Presentations 15 shown
Average cost / item £12.32
Year on year Up 3.1% on a year earlier

What this is

Net ingredient cost is the list price before discounts and dispensing fees, not what the NHS finally pays.

Top presentations, April 2026

The individual products dispensed under Methotrexate this month.

Presentations of Methotrexate, April 2026
Presentation	BNF code	Items	Net ingredient cost
Methotrexate 2.5mg tablets	1001030U0AAABAB	155,704	£235,261
Metoject PEN 20mg/0.4ml inj pre-filled pens	1001030U0BEARBW	9,203	£617,359
Metoject PEN 15mg/0.3ml inj pre-filled pens	1001030U0BEAXCC	6,368	£408,192
Metoject PEN 25mg/0.5ml inj pre-filled pens	1001030U0BEAWCB	6,169	£430,494
Metoject PEN 10mg/0.2ml inj pre-filled pens	1001030U0BEAZCE	2,702	£157,025
Metoject PEN 17.5mg/0.35ml inj pre-filled pens	1001030U0BEAQBV	1,703	£116,647
Metoject PEN 12.5mg/0.25ml inj pre-filled pens	1001030U0BEAYCD	1,329	£85,512
Metoject PEN 22.5mg/0.45ml inj pre-filled pens	1001030U0BEASBX	977	£69,595
Metoject PEN 7.5mg/0.15ml inj pre-filled pens	1001030U0BEATBY	844	£47,465
Methotrexate 10mg tablets	1001030U0AAACAC	398	£2,083
Methofill 20mg/0.4ml inj pre-filled syringes	1001030U0BGAPBH	357	£20,162
Methofill 20mg/0.4ml inj pre-filled injector	1001030U0BGAFBW	321	£20,448
Methofill 15mg/0.3ml inj pre-filled syringes	1001030U0BGAMBG	273	£15,401
Methofill 25mg/0.5ml inj pre-filled syringes	1001030U0BGARBI	219	£13,343
Methofill 15mg/0.3ml inj pre-filled injector	1001030U0BGADCC	176	£10,699

Source: NHSBSA Prescription Cost Analysis · to April 2026 OGL v3.0

Where Methotrexate is dispensed

The regions and dispensing practices with the highest Methotrexate volumes.

Top regions

Top dispensing practices

Regional volumes from NHSBSA Prescription Cost Analysis; practice volumes from NHS dispensing data.

Compare Methotrexate with

Other medicines in the same BNF section, by prescribing volume.

Methotrexate vs Allopurinol Methotrexate vs Naproxen Methotrexate vs Hydroxychloroquine sulfate Methotrexate vs Methylprednisolone acetate Methotrexate vs Ibuprofen