Leflunomide vs Methotrexate
National NHS prescribing compared (Prescription Cost Analysis)
Methotrexate was dispensed 11.1× as often as Leflunomide in May 2026 — 182,888 items versus 16,405 in England.
16,405items
Leflunomide · May 2026
NHSBSA Prescription Cost Analysis
182,888items
Methotrexate · May 2026
NHSBSA Prescription Cost Analysis
Figure 1. Leflunomide versus Methotrexate: national items dispensed by month
▬ Leflunomide · ╌ Methotrexate
Source: NHSBSA Prescription Cost Analysis, to May 2026
| Measure | Leflunomide | Methotrexate |
|---|---|---|
| Items, May 2026 | 16,405 | 182,888 |
| Items, last 12 months | 197,406 | 2,236,227 |
| Net ingredient cost, May 2026 | £206,618 | £2,247,752 |
See the full profile for Leflunomide or Methotrexate.