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Independent analysis of NHS open data
PharmaInsight

Penicillamine vs Methotrexate

National NHS prescribing compared (Prescription Cost Analysis)
Data updated May 2026

Methotrexate was dispensed 467.7× as often as Penicillamine in May 2026 — 182,888 items versus 391 in England.

391items

Penicillamine · May 2026

NHSBSA Prescription Cost Analysis

182,888items

Methotrexate · May 2026

NHSBSA Prescription Cost Analysis

Figure 1. Penicillamine versus Methotrexate: national items dispensed by month

▬ Penicillamine   ·   ╌ Methotrexate

0 99k 198k Jan 2021 Nov 2021 Oct 2022 Aug 2023 Jun 2024 Apr 2025 May 2026 Methotrexate 391 Jan 2021: 572 Feb 2021: 541 Mar 2021: 548 Apr 2021: 573 May 2021: 530 Jun 2021: 601 Jul 2021: 558 Aug 2021: 521 Sep 2021: 553 Oct 2021: 502 Nov 2021: 544 Dec 2021: 558 Jan 2022: 539 Feb 2022: 540 Mar 2022: 569 Apr 2022: 521 May 2022: 561 Jul 2022: 533 Aug 2022: 529 Sep 2022: 527 Oct 2022: 489 Nov 2022: 520 Dec 2022: 523 Jan 2023: 505 Feb 2023: 466 Mar 2023: 516 Apr 2023: 443 May 2023: 516 Jun 2023: 479 Jul 2023: 469 Aug 2023: 497 Sep 2023: 479 Oct 2023: 484 Nov 2023: 487 Dec 2023: 424 Jan 2024: 398 Feb 2024: 478 Mar 2024: 463 Apr 2024: 475 May 2024: 490 Jun 2024: 456 Jul 2024: 494 Aug 2024: 526 Sep 2024: 463 Oct 2024: 482 Nov 2024: 435 Dec 2024: 473 Jan 2025: 466 Feb 2025: 420 Mar 2025: 447 Apr 2025: 425 May 2025: 424 Jun 2025: 453 Jul 2025: 480 Aug 2025: 438 Sep 2025: 435 Oct 2025: 449 Nov 2025: 415 Dec 2025: 452 Jan 2026: 419 Feb 2026: 413 Mar 2026: 426 Apr 2026: 424 May 2026: 391

Source: NHSBSA Prescription Cost Analysis, to May 2026

Penicillamine versus Methotrexate, May 2026
Measure Penicillamine Methotrexate
Items, May 2026 391 182,888
Items, last 12 months 5,195 2,236,227
Net ingredient cost, May 2026 £102,289 £2,247,752

See the full profile for Penicillamine or Methotrexate.