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Independent analysis of NHS open data
PharmaInsight

Topiramate vs Lamotrigine

National NHS prescribing compared (Prescription Cost Analysis)
Data updated May 2026

Lamotrigine was dispensed 4.1× as often as Topiramate in May 2026 — 376,214 items versus 91,872 in England.

91,872items

Topiramate · May 2026

NHSBSA Prescription Cost Analysis

376,214items

Lamotrigine · May 2026

NHSBSA Prescription Cost Analysis

Figure 1. Topiramate versus Lamotrigine: national items dispensed by month

▬ Topiramate   ·   ╌ Lamotrigine

0 199k 397k Jan 2021 Nov 2021 Oct 2022 Aug 2023 Jun 2024 Apr 2025 May 2026 Lamotrigine 91,872 Jan 2021: 86k Feb 2021: 83k Mar 2021: 93k Apr 2021: 90k May 2021: 87k Jun 2021: 92k Jul 2021: 93k Aug 2021: 89k Sep 2021: 92k Oct 2021: 88k Nov 2021: 92k Dec 2021: 97k Jan 2022: 91k Feb 2022: 85k Mar 2022: 97k Apr 2022: 90k May 2022: 95k Jun 2022: 93k Jul 2022: 93k Aug 2022: 95k Oct 2022: 91k Nov 2022: 91k Dec 2022: 94k Jan 2023: 102k Feb 2023: 91k Mar 2023: 101k Apr 2023: 91k May 2023: 98k Jun 2023: 99k Jul 2023: 98k Aug 2023: 98k Sep 2023: 97k Oct 2023: 98k Nov 2023: 100k Dec 2023: 99k Jan 2024: 101k Feb 2024: 96k Mar 2024: 98k Apr 2024: 100k May 2024: 104k Jun 2024: 97k Jul 2024: 105k Aug 2024: 100k Sep 2024: 97k Oct 2024: 102k Nov 2024: 97k Dec 2024: 99k Jan 2025: 100k Feb 2025: 89k Mar 2025: 95k Apr 2025: 95k May 2025: 97k Jun 2025: 95k Jul 2025: 101k Aug 2025: 92k Sep 2025: 97k Oct 2025: 100k Nov 2025: 91k Dec 2025: 100k Jan 2026: 96k Feb 2026: 88k Mar 2026: 97k Apr 2026: 95k May 2026: 92k

Source: NHSBSA Prescription Cost Analysis, to May 2026

Topiramate versus Lamotrigine, May 2026
Measure Topiramate Lamotrigine
Items, May 2026 91,872 376,214
Items, last 12 months 1,144,017 4,485,415
Net ingredient cost, May 2026 £946,679 £3,066,751

See the full profile for Topiramate or Lamotrigine.