Dornase alfa 2.5mg/2.5ml nebuliser liquid ampoules
NHS hospitals in England used £32,350,338 of indicative cost of Dornase alfa 2.5mg/2.5ml nebuliser liquid ampoules in the 12 months to July 2026, about 0.1% of all hospital medicines spend. That is down 6.5% on the previous 12 months.
Indicative cost · 12 months
Quantity (VMP units) · 12 months
Share of hospital medicines spend
Figure 1. Dornase alfa 2.5mg/2.5ml nebuliser liquid ampoules: NHS hospital indicative cost by month (£ millions)
Source: NHSBSA Secondary Care Medicines Data, to July 2026
Cost is indicative — actual hospital medicine prices are commercially confidential, so these figures are estimated from list prices. See methodology.
NHS trusts using Dornase alfa 2.5mg/2.5ml nebuliser liquid ampoules most
By indicative cost over the 12 months to July 2026.
| NHS trust | Indicative cost (12 months) |
|---|---|
| Oxford University Hospitals Nhs Ft | £18,073,161 |
| Guy's & St Thomas' Nhs Foundation Trust | £2,524,098 |
| The Newcastle Upon Tyne Hpl Nhs Found Tr | £1,014,604 |
| King's College Hpl Nhs Foundation Trust | £868,719 |
| Manchester University Nhs Ft | £862,464 |
| Liverpool Heart & Chest Hosp Found Trust | £762,715 |
| Barts Health Nhs Trust | £667,268 |
| University Hospital Southampton Nhs Ft | £639,038 |
| Sheffield Teaching Hospitals Nhs Trust | £606,141 |
| Univ Hpls Bristol Nhs Foundation Trust | £536,393 |
The primary-care picture
Dornase alfa is also dispensed in the community. See the national primary-care prescribing volume, cost and trend on the Dornase alfa medicine page.