Amitriptyline hydrochloride vs Duloxetine hydrochloride

National NHS prescribing compared (Prescription Cost Analysis)

Data updated March 2026

Amitriptyline hydrochloride was dispensed 3.1× as often as Duloxetine hydrochloride in March 2026 — 1,420,123 items versus 460,870 in England.

1,420,123items

Amitriptyline hydrochloride · March 2026

NHSBSA Prescription Cost Analysis

460,870items

Duloxetine hydrochloride · March 2026

NHSBSA Prescription Cost Analysis

Figure 1. Amitriptyline hydrochloride versus Duloxetine hydrochloride: national items dispensed by month

▬ Amitriptyline hydrochloride · ╌ Duloxetine hydrochloride

Source: NHSBSA Prescription Cost Analysis, to March 2026

Amitriptyline hydrochloride versus Duloxetine hydrochloride, March 2026
Measure	Amitriptyline hydrochloride	Duloxetine hydrochloride
Items, March 2026	1,420,123	460,870
Items, last 12 months	16,560,644	5,152,068
Net ingredient cost, March 2026	£1,545,559	£1,495,740