December 2025 in numbers
Dispensed in December 2025
NHSBSA Prescription Cost Analysis
Net ingredient cost, December 2025
NHSBSA PCA
Figure 1. The most-dispensed medicines in England, December 2025
Source: NHSBSA English Prescribing Dataset
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Most-dispensed medicines
Download full month (CSV)| Medicine | Items | Net ingredient cost |
|---|---|---|
| Atorvastatin | 6,924,473 | £6,394,628 |
| Amlodipine | 3,630,090 | £3,153,302 |
| Lansoprazole | 3,341,937 | £3,786,078 |
| Ramipril | 3,204,668 | £3,105,505 |
| Omeprazole | 3,095,236 | £8,623,278 |
| Levothyroxine sodium | 3,075,640 | £3,709,942 |
| Bisoprolol fumarate | 2,767,478 | £2,190,476 |
| Colecalciferol | 2,580,322 | £10,812,631 |
| Metformin hydrochloride | 2,409,141 | £5,979,310 |
| Sertraline hydrochloride | 2,268,252 | £4,242,250 |
| Aspirin | 1,761,778 | £1,587,743 |
| Salbutamol | 1,476,302 | £4,661,362 |
Biggest risers
Largest month-on-month rise in items (medicines above 10,000 items).
| Medicine | Items | Change |
|---|---|---|
| Phenazone/lidocaine | 22,150 | +56.9% |
| Vibegron | 13,570 | +35.1% |
| Ulipristal acetate (Emergency Contraceptive) | 35,223 | +34.0% |
| Amoxicillin | 1,025,727 | +32.0% |
| Doxycycline hyclate | 447,495 | +31.3% |
| Erythromycin ethylsuccinate | 14,887 | +27.9% |
| Amiodarone hydrochloride | 37,784 | +24.5% |
| Prednisolone | 633,577 | +23.2% |
Biggest fallers
Largest month-on-month fall in items.
| Medicine | Items | Change |
|---|---|---|
| Influenza | 1,219,728 | −51.3% |
| Fluorouracil (Sunscreen) | 11,768 | −26.4% |
| Levonorgestrel | 10,272 | −16.0% |
| Diclofenac sodium | 10,890 | −8.9% |
| Sodium fluoride | 114,940 | −5.5% |
| Terbinafine hydrochloride | 21,125 | −4.3% |
| Lymphoedema Garments | 53,553 | −3.6% |
| Miconazole nitrate | 39,317 | −3.4% |
Download this data
Every medicine dispensed in December 2025 is in this month's CSV. For the full monthly history — the national headline series, and the top 500 medicines ranked in every month — see the headline series and most-prescribed medicines datasets in our open data catalogue.