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Independent analysis of NHS open data
PharmaInsight

December 2025 in numbers

NHS community prescribing in England (Prescription Cost Analysis).
Data updated December 2025
114,333,376items

Dispensed in December 2025

NHSBSA Prescription Cost Analysis

£1,020,691,160

Net ingredient cost, December 2025

NHSBSA PCA

Most-dispensed medicines

Download full month (CSV)
Top medicines by items, December 2025
MedicineItemsNet ingredient cost
Atorvastatin 6,924,473 £6,394,628
Amlodipine 3,630,090 £3,153,302
Lansoprazole 3,341,937 £3,786,078
Ramipril 3,204,668 £3,105,505
Omeprazole 3,095,236 £8,623,278
Levothyroxine sodium 3,075,640 £3,709,942
Bisoprolol fumarate 2,767,478 £2,190,476
Colecalciferol 2,580,322 £10,812,631
Metformin hydrochloride 2,409,141 £5,979,310
Sertraline hydrochloride 2,268,252 £4,242,250
Aspirin 1,761,778 £1,587,743
Salbutamol 1,476,302 £4,661,362

Biggest risers

Largest month-on-month rise in items (medicines above 10,000 items).

Biggest risers month on month
MedicineItemsChange
Phenazone/lidocaine 22,150 +56.9%
Vibegron 13,570 +35.1%
Ulipristal acetate (Emergency Contraceptive) 35,223 +34.0%
Amoxicillin 1,025,727 +32.0%
Doxycycline hyclate 447,495 +31.3%
Erythromycin ethylsuccinate 14,887 +27.9%
Amiodarone hydrochloride 37,784 +24.5%
Prednisolone 633,577 +23.2%

Biggest fallers

Largest month-on-month fall in items.

Biggest fallers month on month
MedicineItemsChange
Influenza 1,219,728 −51.3%
Fluorouracil (Sunscreen) 11,768 −26.4%
Levonorgestrel 10,272 −16.0%
Diclofenac sodium 10,890 −8.9%
Sodium fluoride 114,940 −5.5%
Terbinafine hydrochloride 21,125 −4.3%
Lymphoedema Garments 53,553 −3.6%
Miconazole nitrate 39,317 −3.4%