The most-prescribed medicines in England
Top 100 by items · May 2025 – April 2026 · NHS Prescription Cost Analysis
The 100 most-dispensed medicines in England over the 12 months to April 2026, ranked by prescription items. Atorvastatin led with 78,422,885 items; the top 100 together account for 988,314,235 items.
Top 100 medicines
Download CSV| # | Medicine | Items (12 months) | Net ingredient cost |
|---|---|---|---|
| 1 | Atorvastatin | 78,422,885 | £73,398,418 |
| 2 | Amlodipine | 41,320,822 | £35,582,229 |
| 3 | Lansoprazole | 37,974,730 | £43,434,140 |
| 4 | Ramipril | 36,439,767 | £41,429,172 |
| 5 | Omeprazole | 35,512,433 | £98,255,236 |
| 6 | Levothyroxine sodium | 35,043,725 | £43,200,835 |
| 7 | Bisoprolol fumarate | 31,372,888 | £28,579,370 |
| 8 | Colecalciferol | 29,332,524 | £121,789,823 |
| 9 | Metformin hydrochloride | 27,464,818 | £71,315,451 |
| 10 | Sertraline hydrochloride | 25,892,055 | £47,296,029 |
| 11 | Aspirin | 20,282,334 | £30,043,883 |
| 12 | Amitriptyline hydrochloride | 16,601,897 | £18,861,471 |
| 13 | Salbutamol | 16,248,264 | £50,465,587 |
| 14 | Paracetamol | 15,777,004 | £76,666,609 |
| 15 | Co-codamol (Codeine phosphate/paracetamol) | 14,886,389 | £71,727,081 |
| 16 | Mirtazapine | 13,847,196 | £14,080,630 |
| 17 | Losartan potassium | 13,739,680 | £13,807,059 |
| 18 | Influenza | 13,461,420 | £228,877,438 |
| 19 | Citalopram hydrobromide | 12,848,507 | £11,644,284 |
| 20 | Clopidogrel | 12,262,809 | £12,266,112 |
| 21 | Dapagliflozin | 11,869,860 | £237,276,026 |
| 22 | Furosemide | 11,318,863 | £9,227,031 |
| 23 | Apixaban | 11,140,547 | £22,609,949 |
| 24 | Emollients | 10,932,647 | £66,392,399 |
| 25 | Other Appliances | 10,775,993 | £61,967,784 |
| 26 | Simvastatin | 10,161,394 | £10,446,980 |
| 27 | Tamsulosin hydrochloride | 10,122,039 | £13,081,046 |
| 28 | Pregabalin | 10,105,697 | £21,149,825 |
| 29 | Beclometasone dipropionate | 9,831,650 | £226,389,735 |
| 30 | Eye Products | 9,541,984 | £74,377,562 |
| 31 | Folic acid | 9,425,046 | £8,641,508 |
| 32 | Candesartan cilexetil | 8,998,704 | £16,639,860 |
| 33 | Propranolol hydrochloride | 8,379,623 | £26,891,231 |
| 34 | Amoxicillin | 8,271,023 | £11,143,512 |
| 35 | Doxazosin mesilate | 7,859,823 | £25,601,431 |
| 36 | Macrogol 3350 | 7,825,815 | £78,009,164 |
| 37 | Fluoxetine hydrochloride | 7,622,761 | £15,759,486 |
| 38 | Naproxen | 7,541,200 | £22,256,297 |
| 39 | Allopurinol | 7,523,304 | £7,706,891 |
| 40 | Rosuvastatin calcium | 7,516,469 | £14,554,244 |
| 41 | Lisinopril | 7,487,956 | £8,775,746 |
| 42 | Gabapentin | 7,356,812 | £21,676,030 |
| 43 | Fexofenadine hydrochloride | 7,102,854 | £26,997,778 |
| 44 | Estradiol | 6,512,173 | £108,700,298 |
| 45 | Ezetimibe | 6,506,368 | £10,671,175 |
| 46 | Venlafaxine | 6,462,229 | £56,345,044 |
| 47 | Indapamide | 6,202,666 | £26,517,637 |
| 48 | Prednisolone | 6,103,909 | £15,778,907 |
| 49 | Gliclazide | 5,840,171 | £12,237,137 |
| 50 | Codeine phosphate | 5,687,503 | £15,307,873 |
| 51 | Ferrous fumarate | 5,500,467 | £11,140,394 |
| 52 | Duloxetine hydrochloride | 5,205,999 | £16,803,277 |
| 53 | Glucose blood testing reagents | 5,157,172 | £69,758,870 |
| 54 | Alendronic acid | 5,043,794 | £8,544,144 |
| 55 | Tramadol hydrochloride | 5,023,012 | £17,520,197 |
| 56 | Morphine sulfate | 5,012,201 | £29,666,667 |
| 57 | Montelukast | 4,910,808 | £5,461,037 |
| 58 | Budesonide | 4,791,754 | £163,454,603 |
| 59 | Lercanidipine hydrochloride | 4,761,081 | £13,142,606 |
| 60 | Senna | 4,748,410 | £5,733,981 |
| 61 | Bendroflumethiazide | 4,735,952 | £3,365,096 |
| 62 | Rivaroxaban | 4,715,727 | £9,965,301 |
| 63 | Quetiapine | 4,702,226 | £52,179,546 |
| 64 | Empagliflozin | 4,688,045 | £185,428,514 |
| 65 | Famotidine | 4,617,954 | £36,416,175 |
| 66 | Isosorbide mononitrate | 4,565,369 | £21,960,914 |
| 67 | Other emollient preparations | 4,551,280 | £36,507,473 |
| 68 | Finasteride | 4,524,017 | £4,755,672 |
| 69 | Detection Sensor Interstitial Fluid/Gluc | 4,515,153 | £369,003,686 |
| 70 | Lamotrigine | 4,477,211 | £34,058,757 |
| 71 | Nitrofurantoin | 4,433,977 | £30,637,078 |
| 72 | Alginic acid compound preparations | 4,405,541 | £38,190,117 |
| 73 | Spironolactone | 4,217,489 | £15,258,079 |
| 74 | Felodipine | 4,088,415 | £21,847,670 |
| 75 | Carbocisteine | 4,086,396 | £20,482,319 |
| 76 | Zopiclone | 4,074,903 | £2,273,840 |
| 77 | Edoxaban | 4,049,423 | £201,506,956 |
| 78 | Skin Fillers And Protectives | 4,047,236 | £45,582,264 |
| 79 | Ferrous sulfate | 4,031,201 | £6,664,717 |
| 80 | Flucloxacillin sodium | 3,996,110 | £9,830,188 |
| 81 | Doxycycline hyclate | 3,965,000 | £4,772,210 |
| 82 | Thiamine hydrochloride | 3,941,053 | £5,238,187 |
| 83 | Ibuprofen | 3,906,940 | £16,808,103 |
| 84 | Diazepam | 3,796,839 | £5,989,799 |
| 85 | BeclometDiprop/Formoterol/Glycopyrronium (Corticosteroids) | 3,747,404 | £185,521,835 |
| 86 | Atenolol | 3,686,668 | £2,730,053 |
| 87 | Cetirizine hydrochloride | 3,557,454 | £10,240,317 |
| 88 | Solifenacin | 3,544,047 | £5,284,803 |
| 89 | Latanoprost | 3,485,754 | £23,575,570 |
| 90 | Wound Management & Other Dressings | 3,481,316 | £135,308,112 |
| 91 | Perindopril erbumine | 3,414,592 | £7,353,289 |
| 92 | Sildenafil (Erectile Dysfunction) | 3,391,638 | £4,508,572 |
| 93 | Progesterone | 3,363,505 | £42,820,847 |
| 94 | Hydrocortisone | 3,360,956 | £22,722,608 |
| 95 | Levetiracetam | 3,359,957 | £31,830,020 |
| 96 | Hydroxocobalamin | 3,332,987 | £9,473,038 |
| 97 | Tirzepatide | 3,192,628 | £627,107,325 |
| 98 | Mirabegron | 3,146,003 | £85,460,441 |
| 99 | BeclometDiprop/Formoterol | 3,108,812 | £95,992,586 |
| 100 | Sitagliptin | 3,093,129 | £13,687,622 |